Semaglutide is a prescription medication that helps people manage type 2 diabetes and lose weight. You might know it by its brand names, like Ozempic, Wegovy or a similar medication like tirzepatide, also known as Mounjaro or Zepbound. These medications work by helping your body feel fuller longer, lowering your appetite and controlling blood sugar.
“Semaglutide (or tirzepatide) is a synthetic medication that mimics the effect of a hormone called glucagon-like peptide (GLP-1),” said David Podkameni, MD, a bariatric surgeon with Banner - University Medicine. “GLP-1 helps regulate blood sugar and appetite.”
Right now, access to semaglutide is changing. Many compounded versions – used when the name-brand drugs were hard to find – are being banned. That’s leaving some people without the option to continue treatment, even if it’s been working well for them.
If you’re thinking about stopping semaglutide or need to stop because of cost, availability or side effects, here’s what you need to know.
Why do people stop taking semaglutide?
There are a few reasons you might stop taking this medication:
- Cost or insurance coverage: It can be expensive if it’s not covered by your plan.
- Side effects: Some people experience nausea, stomach upset or fatigue.
- Reaching a goal: You may have reached your target weight or your blood sugar is now under control.
- Pregnancy or other health changes: Some people pause medication for safety during pregnancy or other health needs.
What happens when you stop taking semaglutide?
When you stop taking this medication, your body may respond in a few different ways. That’s because you’re no longer getting that extra support.
“We have our own natural supply of GLP-1, but stopping the added GLP-1 from semaglutide can lead to weight gain and changes in how the body manages blood sugar,” Dr. Podkameni said.
Weight gain
“You can stop abruptly with no major consequences, but if the medication was being used for weight loss, you will most likely see some significant weight gain,” Dr. Podkameni said.
Many people notice weight gain soon after stopping semaglutide. That’s because:
- Hunger cues may return quickly
- Cravings can feel stronger
- Metabolism might slow down
- Old eating habits may come back
Blood sugar changes
If you were using semaglutide to manage type 2 diabetes or had borderline blood sugar levels, stopping may affect your glucose control.
That’s because semaglutide helps your pancreas release insulin when needed and slows how quickly food leaves your stomach. Both of these things help keep your blood sugar steady.
When the medication is stopped:
- You may digest carbs more quickly
- Your body may not release insulin as efficiently
- You could feel hungry more often, which may lead to higher sugar intake
These changes can make it harder to keep your blood sugar within a healthy range. That’s why monitoring your blood sugar and staying in touch with your health care provider is important during this transition. They can help you adjust your diet or explore other medications.
Healthy steps to take when stopping semaglutide
It’s possible to maintain your weight after stopping semaglutide — but it takes planning, support, and consistent habits. This transition can feel overwhelming, but you don’t have to navigate it alone.
Many people do better with guidance from professionals. Health care providers and dietitians can help you create a plan that fits your lifestyle, goals and any underlying health needs.
Here are a few healthy steps you can take to stay on track:
Start a food and activity log
Track your meals, snacks and movement. This will help you notice patterns and catch small changes before they become bigger problems.
Try writing down:
- What you eat and when
- How much water you drink
- Your daily exercise or steps
- How you feel emotionally
Follow a balanced meal plan
Focus on nutrition that supports your energy and metabolism.
- Eat lean protein (chicken, fish, beans, tofu)
- Include fiber-rich foods (veggies, fruit, whole grains)
- Stay hydrated
- Avoid skipping meals, which can lead to overeating
- Watch your portions, especially with snacks or treats
If possible, meet with a registered dietitian. They can build a personalized meal plan that works for you.
Keep moving
Exercise doesn’t just burn calories. It also improves your mood and keeps your metabolism strong. Even 15 to 30 minutes days can make a difference.
Try one of the following:
- Walking around your neighborhood
- Swimming or water aerobics
- Stretching or yoga
- Dancing in your living room
- Playing outside with your kids or grandkids
Focus on strength
Lifting weights or doing bodyweight exercises helps build muscle. Muscle burns more calories than fat, which can help you lose weight over time. Ask an athletic trainer or physical therapist for help getting started.
Prioritize sleep and stress
Poor sleep and high stress can increase hunger hormones and cravings. Try to get seven to nine hours of sleep at night. Use stress-reducing tools like deep breathing, stretching, journaling or talking to a therapist.
Talk to your health care provider
There may be other ways to help you manage your weight or blood sugar. Your provider can work with you to find a different medication or change the dose.
“An individualized approach is best,” Dr. Podkameni said. “This might mean decreasing the semaglutide dose and monitoring weight or switching to an oral version while keeping an eye on results.”
Other options may include:
- Medical nutrition therapy
- Bariatric surgery (in some cases)
- Behavioral health support
Takeaway
Choosing whether to stay on semaglutide or stop it is a personal decision. You know your body and your needs best. But having someone support you during your health journey can make all the difference.
Schedule a visit with a Banner Health provider or dietitian. Whether you’re coming off semaglutide or looking for a new plan, our team can help you feel supported, empowered and in control.
